Narcolepsy, idiopathic hypersomnolence and related conditions

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Hypersomnolence and narcolepsy; a pragmatic diagnostic neurophysiological approach.

Out of a group of 250 consecutive patients who were examined for various disorders of sleep and waking at Ghent University Hospital within a period of 24 months, 30 patients with hypersomnolence associated with a suspected underlying neurological etiology were selected. The population consisted of 15 males and 15 females with mean age of 36 years (range: 16-60 years). Twenty-one patients had ha...

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Since the research work of Fischer-Wasels by anatomic methods, we know that in the pathogenesis of so-called idiopathic spontaneous pneumothorax certain bullae, situated on the surface of the lung, play an important part. Later our concept was further extended by pleural endoscopy which made possible not only exact diagnosis, but also effective therapy. We learned by means of biopsy that the bu...

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Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil.

1. Modafinil, a putative central alpha 1 adrenergic agonist, was tested in idiopathic hypersomnia and narcolepsy. 2. Sleep attacks and drowsiness were significantly decreased in 83% of 18 hypersomniac subjects and 71% of 24 narcoleptics. 3. When cataplectic episodes were not totally suppressed the association of a low dose of Clomipramine was successful in improving them. 4. Modafinil, used for...

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ژورنال

عنوان ژورنال: Clinical Medicine

سال: 2011

ISSN: 1470-2118,1473-4893

DOI: 10.7861/clinmedicine.11-3-282